# Compatibility Reference

## Do NOT Combine

| A | B | Reason |
| --- | --- | --- |
| SIBO yogurt | Herbal antimicrobials (berberine, oregano, allicin, neem) | Antimicrobials kill the yogurt's beneficial strains indiscriminately |
| SIBO yogurt | Berberine specifically | Berberine blocks the yogurt's benefits (confirmed by Davis's Inner Circle) |
| NAC / serrapeptase | Ca, Zn, Fe, Mg supplements | Minerals reinforce biofilm matrix. Avoid within 3 hours. Trace amounts in capsule filler (~20-30mg) are negligible and fine. |
| MotilPro / 5-HTP | SSRIs / MAO inhibitors | Serotonin syndrome risk |
| Non-enteric-coated oregano oil | Empty stomach (with reflux) | Worsens reflux — use enteric-coated only |
| Elemental diet | Antimicrobials | Diet starves bacteria dormant; antimicrobials need active replicating bacteria to work |
| Activated charcoal | Any supplement or food | Charcoal binds everything indiscriminately. Must be 2+ hours away from all other supplements and food. |

## Safe Together

| A | B | Why |
| --- | --- | --- |
| SIBO yogurt | Iberogast + ginger + LDN | Different mechanisms, no conflict. Prokinetics support motility; yogurt kills bacteria via bacteriocins. |
| SIBO yogurt | NAC + serrapeptase | Biofilm disruptors don't kill bacteria — they strip shields, giving yogurt's bacteriocins better access to exposed SIBO bacteria. Yogurt strains unharmed. |
| NAC + serrapeptase | Berberine + allicin | Exposed bacteria getting hit by antimicrobials — this is the intended combo for Phase 3. |
| Iberogast | LDN + ginger | Three prokinetics with different mechanisms — can be combined for greater effect. |
| Multiple prokinetics | Each other | Different mechanisms of action. Combining amplifies MMC support. |
| ACV | All supplements | Supports stomach acid environment. No conflicts. |
| Activated charcoal | Nothing within 2 hours | Only use for die-off symptom management, well-spaced from everything else. |

## Phase-by-Phase Compatibility

| Phase | Yogurt | Biofilm Disruptors | Herbal Antimicrobials | Prokinetics |
| --- | --- | --- | --- | --- |
| Phase 1 (Weeks 1-6) | ✅ | ✅ (from week 2) | ❌ | ✅ |
| Phase 2 (Weeks 7-8) | ✅ | ✅ | ❌ | ✅ |
| Phase 3 (Weeks 9-14) | ❌ | ✅ | ✅ | ✅ |
| Phase 4 (Week 15+) | ✅ | ❌ | ❌ | ✅ |